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In the following we describe four key research issues that we will study within SHARP. Three research issues address relevant aspects of Theme 1 and deal with changes in stratospheric dynamics (with focus on the Brewer-Dobson circulation) and chemical composition (with focus on the evolution of stratospheric O3 and H2O). The fourth research topic will deal with the vertical radiative and dynamical coupling between stratosphere and troposphere and the impact of stratospheric changes on tropospheric climate and weather (Theme 2).